- Stun Rod: The Stun Rod is an taser like melee weapon that is cable of shocking someone with one million and a half volts of electricity. This allows for Big Boss to take down soldiers non-lethally, with its small size allowing it to be viable as a CQC weapon.
- Mk. 22 Mod.0 Hush Puppy: The Mk. 22 is a suppressor-equipped pistol modified to be used as a tranquiller gun. It uses a slide-lock mechanism for added noise suppression at the cost of the gun having to be loaded each time it's fired. The tranquiller darts used by the Mk. 22 are able to put someone to sleep in less then a minute after being hit, and can even instantly put someone to sleep if shot in the head. The Mk. 22's suppressor can't be used forever, as it will break after being used for sometime and will have to be replaced.
- M16A1: The M16A1 is a American-made assault rifle that uses 5.56x45mm rounds, giving it a low recoil and making it fairly accurate at the cost of its lower stopping power. The M16M1 is able to be fitted with a suppressor and a laser sight, along with having shotgun, grenade launcher, and smoke grenade launcher variants.
- Fragmentation Grenade: Fragmentation grenades are throwable explosives that are able heavily damage or kill one's target. Once the grenade explodes, it will propel scrap metal in all directions, furthering its lethality.
- Combat Knife: The combat knife is a small blade used for stabbing and slashing at opponents. Its size allows for it to be an effective CQC weapon, where it is usually used to pressure an enemy rather than kill them.
- WU Silent Pistol: The WU Silent Pistol is a pistol equipped with a built-in suppressor that fires tranquiller rounds. Similar to Mk. 22, its rounds will put someone to sleep in less then a minute after being hit and will instantly put someone to sleep if shot in the head. Along with this WU Silent Pistol also has to be reloaded every time the gun is fired. The WU Silent Pistol produces little gas and recoil, allowing for steady aim along with its suppressor being able to be used indefinitely. Due to the gun's low muzzle velocity, it has a limited range compared to most firearms.
- AM MRS-4 Rifle: The AM MRS-4 Rifle, also known as, Arms Material Multi-purpose Rifle System model 4, is an American assault rifle equipped with a scope, flashlight, and suppressor. Its suppressor allows it to be used for stealth missions, though it will quickly break after being fired enough times.
- Flare Grenade: The Flare Grenade, also known as the Type 66 Flare Grenade, is a signal flare grenade used to direct support helicopters to the location it was thrown at.
Int-Scope: The Int-Scope is a pair of binoculars used by Big Boss during his infiltration of Camp Omega. The Int-Scope allows Big Boss to mark his enemies, allowing him to see them through walls and see them on his map.
- Night-Vison Goggles: Night-vision goggles are a type of goggles that allow one to see in the dark by amplifying light and displaying it as images. Night-vision goggles also highlight interactable objects or people in green, making them easier to see. Due to how the goggles amplify light, if one looks into an extremely bright light source such as fire, they can be blinded by said light.
- Flashlight: A portable device used to crate a small source of light. Big Boss used a flashlight during his infiltration of Camp Omega.
- Walkman MP3 Player: The Walkman MP3 Player is a portable audio player developed by Sony. It allows Big Boss to listen to any cassette tapes he finds on his missions.
- Empty Gun Magazines: Big Boss has an infinite supply of empty gun magazines, which he can use to distract enemies by throwing them to lure enemies away.
- Med Spray: The Med Spray is medical spray that is able to heal serious wounds sustained by Big Boss. Big Boss used the Med Spray during his infiltration of Camp Omega.
- M1911A1 Custom: The M1911A1 Custom is a improved variant of the M1911A1. The customizations include the M1911A1's feeding ramp being polished to a mirror sheen, preventing feeding problems, the slide being replaced with a reinforced slide that meshes perfectly with the frame, the frame being iron-welded and scarped down for maximum precision, the frame's front part being checkered to improve grip, an original three dot sight system for better target sighting, the gun hammer being replaced with a ring hammer for better cocking control and faster hammer down speed, with the grip safety being reworked to accommodate for the ring hammer, the thumb safety and slide stop being extended for more precise handling, the base of the trigger guard being whittled down, allowing for the use of a high grip, the trigger being replaced with a long-type trigger for easy finger access and lighter trigger pull, a widened magazine well for easier magazine placement, the magazine catch button has been lower to prevent hitting it by mistake, the mainspring housing being changed to a flat type for increased grip, which was also fitted with stepping so it doesn't slip from the gun's recoil, and added cocking serrations to the front part of the slide for faster cartridge loading. The M1911A1 Custom can be fitted to have a suppressor equipped to it, though it will break overtime when the gun is fired.
- ACM Variant: A M37 Variant equipped with a scope, a choke, and a longer barrel for better power and aim at longer ranges. It fires shotgun slugs instead of buckshot rounds.
- Rubber Slug Variant: A non-lethal variant of the Twin Barrel that fires rubber slugs instead of twelve gauge rounds. Its reload time can be decreased with further upgrades and is effective at longer ranges than its lethal variant.
- Shotgun Variant: A variant of the M653 equipped with a shotgun attachment.
- Grenade Launcher Variant: A variant of the M653 equipped with a grenade launcher attachment.
- Smoke Grenade Launcher Variant: A variant of the M653 equipped with a smoke grenade launcher attachment.
- Grenade Launcher Variant: A variant of the RK-47 equipped with a grenade launcher attachment.
- Smoke Grenade Launcher Variant: A variant of the RK-47 equipped with a smoke grenade launcher attachment.
- Barrel Jacket Variant: A barrel jacket version of the MAC-10 that allows for greater accuracy when firing.
- PSYCHE Recovery Variant: A variant of the M1C that allows Big Boss to restore the PYSCHE of others when firing it at them.
- Night-Vison Variant: A night-vison scope variant of the SVD that allows for sniping in the dark.
- Multi Purpose Variant: A variant of the Carl Gustav that fires HEAT rounds, which cover a greater radius but do less damage to the target. It's great for dealing with multiple targets compared to single, heavy targets.
- Fulton Recovery Variant: A non-lethal variant of the Carl Gustav developed by the United States of America. It uses Fulton rounds to capture the target rather than killing them, taking them out of the battlefield through the use of a self-inflating balloon, where they are then picked up in the sky by a MSF chopper and brought to mother base.
- Colored Smoke Grenade: Colored variants of the Smoke Grenade, which can produce smoke clouds in the colors red, blue, green, yellow, and black.
- MGS Magazine: The MGS Magazine is a popular monthly magazine of the Metal Gear Solid series. In the Japanese version of Metal Gear Solid: Peace Walker, it is known as the MSF magazine.
- Solid Magazine: The Solid Magazine is a sci-fi/horror themed magazine that is half filled with stories written by amateur writers. Due to this, the stories aren't meant to be taken very seriously. The Solid Magazine also includes lurid and suggestive themes within its stories. In the Japanese version of Metal Gear Solid: Peace Walker, it is known as the Weekly Famitsu magazine.
- Liquid Magazine: The Liquid Magazine is a mature magazine that includes travel logs from soldiers across the world and ample pinups. In the Japanese version of Metal Gear Solid: Peace Walker, it is known as the Dengeki PlayStation magazine.
- Solidus Magazine: The Solidus Magazine is a quarterly-issued men's lifestyle magazine aimed at discriminatory adults. It contains articles on various topics such as the news, politics, and special interests. It also contains adult content. In the Japanese version of Metal Gear Solid: Peace Walker, it is known as the Dengeki Games magazine.
- Super Magazine: The Super Magazine is a bi-monthly women's fashion magazine. Due to the models used in the magazine, it has a large male following as well. The cover of the magazine states that it's the 23rd anniversary issue of the magazine. In the Japanese version of Metal Gear Solid: Peace Walker, it is known as the Weekly Shōnen magazine.
- Helmet Variation: A Battle Dress that comes with a bullet proof helmet, further increasing the defense of the Battle Dress.
- FOX: A variation of the T-Shirt with the FOX logo.
- UNIQLO T-shirts: A variation of the T-Shirt designed by the fashion company UNIQLO.
- HORI: A variation of the T-Shirt with the HORI logo.
- Doritos: A variation of the T-Shirt with the Doritos logo.
- Axe: A variation of the T-Shirt with the AXE body spray logo.
- Mountain Dew: A variation of the T-Shirt with the Mountain Dew logo.
- Lawson: A variation of the T-Shirt with the Lawson logo.
- Pepsi Nex: A variation of the T-Shirt with the Pepsi Nex logo
- UB Shirts: Variations of the T-Shirt with anime characters on them. These include the following:
- Arakawa UB ★ Riku Nakamura light: A teal T-shirt depicting Riku Nakamura light that also provides a decent Camo Index in jungle, swamp, and ruins environments.
- UB ★ Nino Arakawa Nakamura light: A blue and white T-shirt depicting Nino Arakawa light that also provides a decent Camo Index in sand, concrete, tree, dirt, and rock environments.
- Star Light ★ UB Arakawa Nakamura: A yellow T-shirt depicting Star Light/Arakawa Nakamura that also provides a decent Camo Index in sand, swamp, tree, dirt, and rock environments.
- Light ★ Nakamura mayor Arakawa UB: A green and white T-shirt depicting Nakamura mayor Arakawa UB that also provides a decent Camo Index in sand, jungle, swamp, and ruins environments.
- UB ★ Sister Arakawa Nakamura light: a black and purple T-shirt depicting Sister Arakawa Nakamura Light that also provides a decent Camo Index in jungle, concrete, swamp, tree, dirt, and ruins environments.
- UB ★ Maria Arakawa light Nakamura: A pink T-shirt depicting Maria Arakawa light Nakamura that has a terrible Camo Index in most environments.
- Monster Hunter T-shirts: Variations of the T-Shirt with various Monster Hunter designs. Created to commemorate the release of Monster Hunter 3rd Portable, these include the following:
- Monster T-shirt Hunter: A Monster Hunter T-shirt that is dark green and has dark Kanji on the back of it.
- Monster T-shirt Soul Hunt: A Monster Hunter T-shirt that is black with white Kanji on the back of the shirt, while also having a unique design on it.
- Monster T-shirt Festival Hunt: A Monster Hunter T-shirt that is blue with yellow Kanji on the back of the shirt, while also having a unique design on it.
- Monster T-shirt friend "temporary": A Monster Hunter T-shirt that is red with white Kanji on the back of the shirt, while also having a unique design on it.
- Leaf: A variation of the Naked camouflage that increases the Camo Index in jungle environments, though not to the extent of its full body counterpart.
- Tiger Stripe: A variation of the Naked camouflage that increases the Camo Index near soil, grass, and even water, though not to the extent of its full body counterpart.
- Choco Chip: A variation of the Naked camouflage that increases the Camo Index in dessert and mountain environments that have sand and dirt, though not to the extent of its full body counterpart.
- Desert Auscam: A variation of the Naked camouflage that increases the Camo Index in desert and rocky environments, though not to the extent of its full body counterpart. It also doesn't have the damage reduction capabilities of its full body counterpart.
- Squares: A variation of the Naked camouflage that increases the Camo Index in urban areas, though not to the extent of its full body counterpart.
- Splitter: A variation of the Naked camouflage that increases the Camo Index near steel and stone materials, though not to the extent of its full body counterpart.
- Snake: A variation of the Naked camouflage that provides a high Camo Index in a variety of environments, though not to the extent of its full body counterpart. It also doesn't greatly increase the Camo Index when crawling like its full body counterpart.
- Pink: A variation of the Naked camouflage that provides a high Camo Index in environments of the same color, though not to the extent of its full body counterpart.
- Black: A variation of the Naked camouflage that provides a high Camo Index in environments of the same color, though not to the extent of its full body counterpart.
- Navy Blue: A variation of the Naked camouflage that provides a high Camo Index in environments of the same color, though not to the extent of its full body counterpart.
- White: A variation of the Naked camouflage that provides a high Camo Index in environments of the same color, though not to the extent of its full body counterpart.
- Red: A variation of the Naked camouflage that provides a high Camo Index in environments of the same color, though not to the extent of its full body counterpart.
- Yellow: A variation of the Naked camouflage that provides a high Camo Index in environments of the same color, though not to the extent of its full body counterpart.
- Khaki: A variation of the Naked camouflage that provides a high Camo Index in environments of the same color, though not to the extent of its full body counterpart.
- Green: A variation of the Naked camouflage that provides a high Camo Index in environments of the same color, though not to the extent of its full body counterpart.
- Water: A variation of the Naked camouflage that provides a high Camo Index when under or near water, though not to the extent of its full body counterpart.
- Tree Bark: A variation of the Naked camouflage that provides a high Camo Index when Snake is pressed up next to a tree, though not to the extent of its full body counterpart.
- DPM: A variation of the Naked camouflage that provides a high Camo Index in forest areas, though not to the extent of its full body counterpart. It also doesn't have the LIFE regeneration capabilities of its full body counterpart.
- Spicy: Spicy Curry, also known as Bon Curry in the Japanese version of Metal Gear Solid: Peace Walker, is the Ranks 1-2 version of Curry, healing the least amount of LIFE out of all curry variations.
- Great: Great Curry, also known as Bon Curry Gold in the Japanese version of Metal Gear Solid: Peace Walker, is the Ranks 3-4 version of Curry, healing an average amount of LIFE compared to the other curry variations.
- Future: Future Curry, also known as Bon Curry Neo in the Japanese version of Metal Gear Solid: Peace Walker, is the Rank 5 version of Curry, healing the most amount of LIFE out of all curry variations.
- Stun Cannon Variant: A variant of the Box Tank that fires a non-lethal projectile that releases a large flash of light that overwhelms the enemy's senses and knocks them out.
- Smoke Shell Variant: A variant of the Box Tank that fires smoke shells, which releases a cloud of smoke to obstruct the enemy's vison while also hiding the user.
- Colored Variant: A colored variant of the Ballistic Shield.