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When Saitama and Genos arrive at the House of Evolution's secret base and subsequently destroy it, Dr. Genus decides that the only way to stop them and gain a sample of Saitama's DNA would be to unleash Carnage Kabuto. After killing many of the clones, Dr. Genus releases Carnage Kabuto, begging him to get Saitama's body at any cost. Carnage Kabuto taunts Dr. Genus, saying that he is far more superior than them, but led by his desire for combat and killing, Carnage Kabuto accepts.
After Saitama and Genos have entered the lair, Carnage Kabuto is seen running down the hallway carrying Genus. After asking him which of the two is Saitama, Kabuto drops Genus and smashes Genos into the wall of the tunnel, embedding his torso and head into it. Kabuto then challenges Saitama to a fight in a nearby chamber, and he agrees based on the fact that Carnage Kabuto made Genos look like "modern art". Carnage Kabuto and Saitama get to the chamber and the fight is about to start when Genos, from the doorway, blasts Kabuto with a large wave of fire. Genos then rushes towards Carnage Kabuto and uses his Machine Gun Blows ability, which has no visible effect on Kabuto. Kabuto then throws a single punch at Genos and smashes him to the ground, breaking apart the left side of his face.
Genos, after recovering from the blow, attempts to shoot another fire blast at Carnage Kabuto, but Kabuto blows on it and sends it right back to Genos, causing his hair to puff up into an afro. Saitama finally steps in to fight and Carnage Kabuto rushes in and is about to smash Saitama, but he senses his aura and jumps back across the room, revealing that he was able to tell that if he had attacked that he would have died. In fear, he asks Saitama why he's so strong. Saitama agrees and tells Kabuto and Genos how he became that strong and reveals his infamous training technique. Carnage Kabuto believes that Saitama is making fun of him and goes into what he calls "Carnage Mode," a form that makes him much larger and alters his appearance greatly. Carnage Kabuto says that he will stay in this form, rampaging until next Saturday. Dr. Genus looks at this in dismay, knowing that Carnage Kabuto's Carnage Mode cannot be stopped. Carnage Kabuto then proceeds to attack Saitama ruthlessly, smashing him around the room, until Saitama realizes that it's Saturday and not Friday and that he might have missed the special sale at the market and proceeds to punch Carnage Kabuto so hard it disintegrates the middle of Kabuto's chest, neck and head, marking the sudden end of Kabuto.
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