Superhuman Physical Characteristics, Power Absorption (All “Your Sanctuary” bosses suck all of the energy out of each sanctuary spot), Poison Manipulation (Can bite with his poisonous fangs, dealing poison damage).
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| “ | The Plague Rat of Doom uses SMASH attacks frequently. Keep yourself healed up and in the fight. Use your top Fire and Flash PSI powers. | „ |
| ~ Plague Rat of Doom’s EarthBound Player's Guide description |

Plague Rat of Doom is the fifth Sanctuary Boss in MOTHER (localized as EarthBound and guards the fifth Your Sanctuary location in the game, Magnet Hill. Like other rat enemies in EarthBound, the Plague Rat of Doom's guts stat is maxed out at 250, making it extremely likely to land critical hits. Once it has been defeated, Ness and his friends may record the melody of Magnet Hill on the Sound Stone.
Name: Plague Rat of Doom
Origin: MOTHER 2
Gender: Male
Age: Unknown
Classification: Boss
Species: Rat
State of Being: Regular
Occupation: Sanctuary Guardian
Affiliations: Giygas
Enemies: Ness
Status: Alive
Alignment: Lawful Evil (Sanctuary Guardians are under the influence of Giygas and have stole Ness' sanctuary locations)
Threat Level: Metropolitan Threat (Sanctuary Guardians pose threats over entire towns they're near and are the boss of the entire dungeon area, which are normally multi-leveled cave systems)
Grade: A
Tier: 8-C
Cardinality: Finite
Dimensionality: 3-D
Attack Potency: Buiding level (Potency) (Absorbed all the energy from a sanctuary location which is a powerful spot that allows the user to perform “wondrous feats” according to Frank, can fight Ness, who can fight and defeat the Kraken, who massively dwarfs an entire ship in size)
Durability: Buiding level
Striking Strength: Building Class (Potency)
Lifting Strength: Unknown
Travel Speed: Unknown
Attack Speed: At least Transonic (Can tag Ness)
Reaction Speed: At least Transonic
Stamina: Unknown
Range: Standard Melee, possibly Higher with PSI
Intelligence: Unknown (Has drained energy from the Your Sanctuary location but has no PSI)
Superhuman Physical Characteristics, Power Absorption (All “Your Sanctuary” bosses suck all of the energy out of each sanctuary spot), Poison Manipulation (Can bite with his poisonous fangs, dealing poison damage).
Standard Tactics: Will scatter spores and disrupt one’s concentration while bashing them and using PSI to heal itself.
Weaknesses: PSI users need to concentrate in order to use their PSI[2].
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